An Introduction to Liraglutide

Posted by: admin on: October 31, 2011

In recent years diabetes is prevailing widely and has become matter of concern. Newer and newer drugs are coming to control diabetes. Recent introduction of Liraglutide seems to be promising.


Liraglutide, a once-daily human glucagon-like peptide-1 (GLP-1) analog, was approved by the US Food and Drug Administration in 2010 for the treatment of type 2 diabetes mellitus (T2DM). Glucagon-like peptide-1 enhances insulin secretion and inhibits glucagon in a glucose-dependent manner. The efficacy and safety of liraglutide were evaluated with sitagliptin and in another trial where basal insulin was added to liraglutide + metformin.

At liraglutide doses of 1.2 mg or 1.8 mg once daily, significant mean reductions in glycated hemoglobin (HbA1c) (1%–1.6%) and fasting plasma glucose (15–43 mg/dL), as well as sustained weight loss (2–3 kg) and a low rate of hypoglycemia occurred. Liraglutide provide an important expansion of options for the treatment of T2DM.



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