Fixed-combination of amlodipine and diuretic chronotherapy in the treatment of essential hypertension: improved blood pressure control with bedtime dosing-a multicenter, open-label randomized study
Posted by: admin on: October 6, 2011
Previous studies have demonstrated that individual anti-hypertension medications have different effects when administered in the morning vs. the evening. However, the impact of administration timing on fixed combinations of anti-hypertensive medications on blood pressure control is still unknown.
In the present study, we examined the administration time-dependent effects of a fixed combination of amlodipine and diuretics (amlodipine complex) on blood pressure in hypertensive subjects. Eighty patients from Chongqing City were enrolled in this study.
FDA regulation, and off label use of atypical antipsychotic drugs
Posted by: admin on: October 6, 2011
Abilify, Seroquel, Zyprexa, Risperal – these are among the atypical antipsychotics for which Americans paid $10 billion in 2008. $6 billion of that was for off-label use.
The FDA only approves drugs when their safety and efficacy have been tested for specific conditions. For example, an antipsychotic might be approved for the treatment of schizophrenia. When it’s prescribed for anxiety or depression, that’s an off-label use.
Evidence for Methotrexate as a Useful Treatment for Steroid-dependent Chronic Urticaria;
Posted by: admin on: October 5, 2011
Chronic urticaria is a relatively common disorder that can be severe and may impair quality of life. The management of recalcitrant chronic urticaria that is not responding to histamine antagonists includes short-term systemic corticosteroids, anti-inflammatory drugs (colchicine, dapsone and sulfasalazine) and immunomodulatory agents, such as cyclosporine, methotrexate, plasmapheresis and intravenous immunoglobulin.
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Effect of Gastric Bypass Surgery on the Absorption and Bioavailability of Metformin
Posted by: admin on: October 5, 2011
OBJECTIVE Use of gastric bypass surgery is common and increasing. Over 40% of patients in diabetes remission after gastric bypass surgery may redevelop diabetes within 5 years. Metformin, the first-line drug for diabetes, has low bioavailability and slow, incomplete gastrointestinal absorption. We hypothesized that gastric bypass would further reduce the absorption and bioavailability of metformin.
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Disease Management Trend Positive for Prefilled Syringes and Unilife
Posted by: admin on: October 5, 2011
The sickest 5% of Americans account for over 40% of U.S. healthcare spending. The goal of disease management is to reduce costs and/or improve quality of life of patients afflicted with chronic diseases like congestive heart failure, cancer and chronic renal disease.
Disease management is a system of coordinated health care interventions that emphasizes outpatient care. The ability of patients to self-administer prescription medication in their own homes, rather than in a healthcare facility delivers several major benefits. In particular, it can significantly reduce the cost of healthcare treatment, reduce the burden on healthcare workers and enhance the overall quality of patient care. As such, disease management is the fastest growing sector of the healthcare product and services field.
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