A comparative study of lNG-IUS (12)(16) and Mirena

Posted by: admin on: April 30, 2012

Three intrauterine contraceptive devices releasing various microgram levels of progesterone were compared in a study in 5 European countries. Read on to know more.


OBJECTIVE: To identify an appropriate dose for a new contraceptive levonorgestrel intrauterine system (LNG-IUS).

PATIENT(S): Parous or nulliparous women aged 21-40 years.

INTERVENTION(S): Treatment with LNG-IUSs with initial in vitro release rates of 12 or 16 μg/d (LNG-IUS12/16) or 20 μg/d (Mirena).

MAIN OUTCOME MEASURE(S): Pearl index, bleeding profile, ease/pain of placement/removal, adverse events.

RESULT(S): A total of 738 subjects had an LNG-IUS placed (LNG-IUS12, n = 239; LNG-IUS16, n = 245; Mirena, n = 254). One, 5, and 0 pregnancies occurred in the LNG-IUS12, LNG-IUS16, and Mirena groups, respectively).

CONCLUSION(S): LNG-IUS12 and LNG-IUS16 provided effective contraception, acceptable bleeding patterns, and were well tolerated compared with Mirena.

Ref: http://www.docguide.com/randomized-phase-ii-study-describing-efficacy-bleeding-profile-and-safety-two-low-dose-levonorgestre?hash=80445d1a&eid=24262&alrhash=2efbb8-880279c42369cc2f8adcb48a6daaf3d2

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