Posted by: admin on: January 30, 2012
A study on albuminuria among the hypertensives on CCB showed that Nifedipine and Clinidipine are superior as kidney protectors than other CCBs.
Team@CMHF
At the intervention for cardiovascular disease (CVD), albuminuria is a new pivotal target. Calcium channel blocker (CCB) is one of the most expected agents. Currently CCBs have been classified by delivery system, half-life and channel types. We tested anti-albuminuric effect among 4 types of CCBs.
METHODS: Subjects were 50 hypertensives (SBP/DBP 164.7±17.1/92.3±12.2mmHg, s-Cr 0.81±0.37mg/dl, urinary albumin excretion (UAE) 69.4 (33.5-142.6) mg/gCr).
Four CCBs were administered in a crossover setting: nifedipine CR, cilnidipine, efonidipine, and amlodipine.
RESULTS: Comparable BP reductions were obtained. UAE at endpoints were as follows nifedipine CR 30.8 cilnidipine 33.9 (efonidipine 51.0 (amlodipine 40.6).
CONCLUSIONS: It is revealed that only nifedipine CR and cilnidipine could reduce albuminuria statistically. Thus, it is suggested that the 2 CCBs might be favorable for organ protection in hypertensives.
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