Posts Tagged ‘Obesity’
Should the FDA have rejected Contrave?
Posted by: admin on: October 13, 2011
by Daniel J. Carlat, MD Recently, the FDA has rejected another anti-obesity drug, Contrave, because of concerns that it might cause heart attacks in patients who take it for years. FDA’s excessive caution was motivated by its experience having been burned by the Fen-Phen fiasco. This was a weight loss drug widely prescribed in the […]
Effect of Gastric Bypass Surgery on the Absorption and Bioavailability of Metformin
Posted by: admin on: October 5, 2011
OBJECTIVE Use of gastric bypass surgery is common and increasing. Over 40% of patients in diabetes remission after gastric bypass surgery may redevelop diabetes within 5 years. Metformin, the first-line drug for diabetes, has low bioavailability and slow, incomplete gastrointestinal absorption. We hypothesized that gastric bypass would further reduce the absorption and bioavailability of metformin.
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