Being one of the common antidepressants in use clinical efficiency and safety of paroxetine was reviewed and has not been found safe.

Team@CMHF

Introduction: A growth in the market for antidepressants, paired with an ever-increasing population affected from depressive disorder, requires a critical re-evaluation of most prescribed antidepressants… Paroxetine represents a widely prescribed and reliable antidepressant for the expert clinician, but the latest data do not rank it amongst the most effective and tolerable newer antidepressants.

Areas covered: This paper reviews latest data on paroxetine and investigates its clinical efficacy and safety in different groups of patients.

Expert opinion: In previous subanalysis and metaregression analysis, paroxetine failed to show clear differences in terms of efficacy across clinical subgroups. Since prescription is still based mainly on its side-effect profile, newer and more accurate directions for an individualized prescription are needed.

Ref: http://www.docguide.com/paroxetine-treatment-depression-critical-update?hash=80445d1a&eid=24504&alrhash=2efbb8-880279c42369cc2f8adcb48a6daaf3d2