Researchers at Albert Einstein College of Medicine of Yeshiva University and NYU School of Medicine have found that high levels of triglycerides (blood fats) are the strongest risk factor for the most common type of stroke in older women – more of a risk factor than elevated levels of total cholesterol or of low-density lipoprotein (LDL) cholesterol

-Team@CMHF

• Strokes involve the sudden loss of blood flow to an area of the brain.
• According to the Centers for Disease Control and Prevention, nearly 800,000 Americans suffer a stroke each year.
• Stroke is the third leading cause of death for both men and women in the United States, accounting for more than 140,000 deaths per year.
• Ischemic strokes, the type assessed in this study, account for more than eight in ten strokes over all and occur when blood clots obstruct blood vessels to the brain.
• Nearly three-quarters of all strokes occur in those over 65.
• Abnormal levels of triglycerides and other lipid biomarkers have long been associated with increased risk for heart disease and atherosclerosis (plaque buildup inside arteries).
• The study’s senior author, Sylvia Wassertheil-Smoller, PhD, said that until this study, researchers had not examined how these lipid biomarkers are independently related to stroke risk in a single group of people.
• The Einstein researchers analyzed data from the Hormones and Biomarkers Predicting Stroke (HaBPS) study, which is comprised of the first 972 women who experienced an ischemic stroke while participating in the WHI.
• These women were matched with a control group of 972 participants who had not had strokes.
• All the women had donated blood samples when they first enrolled in the WHI, and these samples were analyzed for lipid biomarkers.
• It’s important to note, many of the traditional measures of cholesterol that physicians use including total cholesterol and LDL cholesterol were not associated with risk of ischemic stroke, said lead author of the study, Jeffrey S Berger, MD, assistant professor of medicine at the NYU School of Medicine.
• Currently, there is a lack of data that lowering triglyceride levels can help reduce the risk.
• We believe future studies of people with elevated triglyceride levels are warranted to show the reduction of ischemic stroke.
• Dr Wassertheil-Smoller and her colleagues found that women in the highest quarter of baseline triglyceride levels were nearly twice as likely to have suffered an ischemic stroke as women in the lowest quarter of triglyceride values.
• Levels of total cholesterol and LDL (bad) cholesterol were not associated with stroke risk.
• The bottom line is that postmenopausal women and their physicians need to pay attention to triglyceride levels, Dr Wassertheil-Smoller said.
• Women with elevated levels of triglycerides face a greater risk for heart disease and heart attacks than men do.
• This study has underlined the importance of abnormal triglyceride levels by establishing them as an independent risk factor for stroke.
• Elevated triglyceride levels can be triggered by genetic factors or behavioral habits but can be successfully treated with medication and dietary and lifestyle changes, Dr Smoller pointed out.

For further reading log on to
http://www.sacbee.com/2012/02/02/4234908/high-triglyceride-levels-found.html