Paroxetine in Depression -Safety Questioned

Posted by: admin on: May 1, 2012

Being one of the common antidepressants in use clinical efficiency and safety of paroxetine was reviewed and has not been found safe.


Introduction: A growth in the market for antidepressants, paired with an ever-increasing population affected from depressive disorder, requires a critical re-evaluation of most prescribed antidepressants… Paroxetine represents a widely prescribed and reliable antidepressant for the expert clinician, but the latest data do not rank it amongst the most effective and tolerable newer antidepressants.

Areas covered: This paper reviews latest data on paroxetine and investigates its clinical efficacy and safety in different groups of patients.

Expert opinion: In previous subanalysis and metaregression analysis, paroxetine failed to show clear differences in terms of efficacy across clinical subgroups. Since prescription is still based mainly on its side-effect profile, newer and more accurate directions for an individualized prescription are needed.


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