Treating major depressive disorder with 2 medications is common practice. But recent study results showed that antidepressant monotherapy is better than combination therapy to treat major depressive disorder.

Team@CMHF

Combination antidepressant treatment using 2 antidepressants appears to offer no advantage over monotherapy in patients with major depressive disorder (MDD) and may even do more harm than good, new research suggests.
A large-scale trial showed that when treatment in patients with MDD is initiated, a single antidepressant produced the same remission rate as 2 antidepressants and that therapy with 2 drugs may have more side effects than a single drug.

The investigators found no clinical advantage over monotherapy from either combination of antidepressant medications in terms of either remission or response rates.
Professor and chairman of psychiatry at the University of Texas Southwestern Medical Center at Dallas, writes “there seems not to be an easy or a universal answer” to the question of whether polypharmacy is good treatment.

Reference: http://www.medscape.com/viewarticle/745970?src=mpnews&spon=34