Efficacy and safety of bazedoxifene for postmenopausal osteoporosis

Posted by: admin on: December 6, 2011

A selective estrogen receptor modulator (SERM) bazedoxifene is on the trial, to be approved as a drug for prevention of postmenopausal osteoporosis. Here is an article showing the clinical efficacy and safety of bazedoxifene in the treatment of postmenopausal osteoporosis.

   Team@CMHF

  • Bazedoxifene, has been developed to have favorable effects on bone and the lipid profile while minimizing stimulation of uterine or breast tissues.
  • Two large Phase III clinical trials showed that bazedoxifene, as well as raloxifene, increased bone mineral density, decreased levels of bone turnover markers, and significantly reduced the risk of new vertebral fractures in postmenopausal women compared with placebo.
  • Although the incidence of nonvertebral fractures with bazedoxifene or raloxifene did not differ significantly from that with placebo, a post hoc analysis of a subgroup of women at higher fracture risk revealed that bazedoxifene significantly reduced the nonvertebral fracture risk relative to placebo and raloxifene.
  • Bazedoxifene also improved the lipid profile by reducing the serum concentrations of total cholesterol and low–density lipoprotein cholesterol, with an increase in the serum level of high–density lipoprotein cholesterol.
  • The incidences of vasodilatation (hot flushes), leg cramps, and venous thromboembolic events were significantly higher with bazedoxifene and raloxifene compared with placebo.
  • There was no evidence of endometrial and breast stimulation with bazedoxifene.
  • Taking advantage of the favorable effects of bazedoxifene on the breast and endometrium, the pairing of bazedoxifene with conjugated estrogens is under investigation for the treatment of menopausal symptoms and prevention of postmenopausal osteoporosis.
  • A Phase III trial showed that combination therapy of bazedoxifene and conjugated estrogens significantly increased bone mineral density and decreased bone turnover markers, with relief of hot flushes and improvement of vaginal atrophy.

Ref: http://www.mdlinx.com/family-medicine/xml-article.cfm/3653281?utm_source=twitterfeed&utm_medium=twitter

Leave a Reply

Your email address will not be published. Required fields are marked *

*

CMHF Accredited by Maharashtra Medical Council

Subscribe to our Posts

Enter your email address:



  • drchasrani: Difficult to get such a data, authenticated at that. Try Times of India online library
  • rakesh pore: hi, where can i get genuine information about "10 most common drugs sold in india?" i want it for a local project
  • nilesh dutta: sir, Plz give detail about MBA Sports Management Thanks and Regards

Events

  • No events

Calculate Your Body Mass Index



Check your Body Mass Index »

    Grapefruit - 48 kcal in 100g
    48kcal
    Grapefruit - 48 kcal in 100g
    by Noni

Calendar

December 2011
M T W T F S S
« Nov   Jan »
 1234
567891011
12131415161718
19202122232425
262728293031