Combination therapy for dyslipidemia

Posted by: admin on: September 8, 2011

Here is a study on treatment with statins monotherapy and statins in combination therapy for dyslipidemia. Combination therapy has been found to be more useful

Team@CMHF

PURPOSE OF REVIEW Residual cardiovascular risk remains in individuals treated with statins and combination therapies may reduce this risk further

RECENT FINDINGS Most previous trials of combination therapies have shown a favorable effect on lipid profiles without clinical superiority over statin monotherapy.

Trial design has been hampered by short duration and comparison with a low dose statin. The Study of Heart and Renal Protection trial has recently reported findings and shows a benefit of ezetimibe/simvastatin over simvastatin alone.

AIM-HIGH (Atherothrombosis Intervention in Metabolic syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes), a trial of statin/niacin, has been prematurely halted for futility.

Finally, combining a statin with both niacin and ezetimibe shows significant enhancement of the therapeutic effect on lipid profiles.

SUMMARY Current evidence continues to support initiation of a potent statin with titration to achieve targets. Combinations may be useful in individuals unable to reach desired lipid levels on maximal tolerated doses of statins.

Ref: http://www.docguide.com/combination-therapy-dyslipidemia?hash=80445d1a&eid=21589&alrhash=2efbb8-880279c42369cc2f8adcb48a6daaf3d2

Leave a Reply

Your email address will not be published. Required fields are marked *

*

CMHF Accredited by Maharashtra Medical Council

Subscribe to our Posts

Enter your email address:



  • drchasrani: Difficult to get such a data, authenticated at that. Try Times of India online library
  • rakesh pore: hi, where can i get genuine information about "10 most common drugs sold in india?" i want it for a local project
  • nilesh dutta: sir, Plz give detail about MBA Sports Management Thanks and Regards

Calculate Your Body Mass Index



Check your Body Mass Index »

    Grapefruit - 48 kcal in 100g
    48kcal
    Grapefruit - 48 kcal in 100g
    by Noni