Reliability of oupatient endometrial brush cytology vs biopsy in postmenopausal symptomatic women

Posted by: admin on: May 17, 2011

OBJECTIVE: To compare outpatient endometrial sampling cytology with conventional biopsy in postmenopausal women with abnormal uterine bleeding and/or abnormal endometrial thickness at ultrasound.

Endometrial cytologic sampling was performed using a brush device (EBC) while endometrial histological sampling was retrieved using a Novak curette.

RESULTS – Evidence in score pain differences between brush and curette endometrial samples were observed: 50% of patients undergoing brush cytology had lower pain scores whereas 60% of patients undergoing endometrial biopsy had higher pain scores. The failure rate in performing procedures was 8.0% vs 4.1%, and the results were statistically significant on the McNemar test, respectively p = .01 and p = .001.

A non-diagnostic specimen was obtained in 3.9% of cases by EBC, and 10.3% of cases by the Novak curette.

Cytological evaluation had a sensitivity of 100%, specificity of 99%, positive and negative predictive value of 97% and 100% for diagnosing malignant neoplasia. Cytology had high diagnostic accuracy for atypical hyperplasia: sensitivity 100%, specificity 99%, positive and negative predictive value 83% and 100%, respectively.

CONCLUSION-SEBC is a reliable, well tolerated outpatient diagnostic tool for endometrial sampling in detecting early-stage cancer in postmenopausal patients at high risk for endometrial cancer.


Leave a Reply

Your email address will not be published. Required fields are marked *


CMHF Accredited by Maharashtra Medical Council

Subscribe to our Posts

Enter your email address:

  • drchasrani: Difficult to get such a data, authenticated at that. Try Times of India online library
  • rakesh pore: hi, where can i get genuine information about "10 most common drugs sold in india?" i want it for a local project
  • nilesh dutta: sir, Plz give detail about MBA Sports Management Thanks and Regards

Calculate Your Body Mass Index

Check your Body Mass Index »

    Lemon - 30 kcal in 100g
    Lemon - 30 kcal in 100g
    by Noni